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April 1, 2007

Saving Giovanni Day +11

 

Giovanni woke up several times last night for mom requiring oxygen once, more pain medication, and a few diaper changes. He's still laboring to breath, chest heaving and rapid, and battling a fever, which is now 101. A new antibiotic was added last night.

 

Giovanni broke his fever midmorning but still has an infection. As a matter of fact, mom had him smiling and kicking when she sung him the Puck Puck song and he later sat in his swing watching movies.

 

He fought sleep all day, his pain meds were increased again, his breathing is still hard requiring more oxygen today, and he's having a tough time purging the mucositis from his respiratory tract, which is why he laboring to breath. Day +10 was terrifying, day +11 is better, but Giovanni still looks weak and you can see he's suffering from the mucositis. He's really fighting now and you can see it when he looks at you. He's almost pleading for help but its seems like he knows you can't help him and he must overcome himself. Its a terrible thing to watch. Day +11 is gone and Day +12 here. Hopefully he will improve as we approach +15.  

 

March 31, 2007

Saving Giovanni Day +10

 

The morning began with alarm when Giovanni registered a 102.2 fever. His chest heaving as he tried to cough up mucus, struggling, ozzing from the corners of his lips I wiped it away with napkins soaked in Dasani water--the only water he can drink or be wiped with because its filtered. As I held Giovanni  he looked up at me pleading his eyes just stabbing me in the heart. The doctors came in and think the central line may be infected again and need removal. At this point in the transplant process a medical procedure is not welcome, but if needed it must be done. 

 

At this moment Giovanni is being treated with antibiotics, Tylenol for the fever, and he's being closely monitored. His vitals are all good but his chest is heaving too much for my comfort. He simply looks uncomfortable, weak, and helpless... A grown man having survived 17 1/2  years of hell through the bowels of two prison systems and I'm scared for my son's life. I'd beg on my hands and knees,sell my soul, any and every temporal possession I own to take his place if anyone could deliver me there.   

 

Giovanni broke the fever, its down to 98. He's still laboring to purge the mucositis from his throat and heaving as he breathes, his bottom is still broken down and sore, but the alarms within Christina and I have silenced. This is the true horror of the transplant process day to day. You wait in a state of unknown, uncertainty, an unsettling fear that engulfs your entire being and preoccupies your every thought hoping there's no changes and then enter a state of shaking terror that crawls over your entire body upon the delivery of any news that can lead of culminate in fatality. Your mind racing through a multitude of scenarios you endeavor to weigh and reason to attain a semblance of selfish relief from your fear. 

 

I keep getting up from the computer and walking to Giovanni looking at him as labors to breath and ever so often he opens his eyes looking up having caught me in worry. The doctors are concerned with his breathing and have ordered an x-ray. His fever is climbing again, now he's crying. I must go for now.  

 

Giovanni is free of fever, his chest x-ray is clear, and the blood test shows his blood is adequately oxygenated. His vitals are stable and a blood cultures was drawn but it will take 24 hours before we know if there's an infection. Giovanni is having a rough time purging the mucositis from his system, he is suffering, The pain meds are coming more frequently but he's fighting them to stay a wake. I rubbed his head until he allowed the drugs to overcome him and allow him to rest. 

 

Mom is with Giovanni and me now and he's resting comfortably in her arms. He knows and loves his momma even through a drug induced fog. I'll report the blood culture as soon as we know. Day +10 is one of the toughest day's Giovanni has had so far, day +11 is coming.

 

Giovanni has spiked another fever, 101.2, and his blood culture came back positive for a gram positive infection, which is not as serious as his previous gram negative infection requiring the immediate removal of his central line. Nonetheless, new antibiotics were started, his breathing is still rapid, almost a heaving of the chest with deep retractions in the diaphram. He is putting up a serious fight and even though barely lucid given the degree of pain medication he periodically opens his eyes recognizing Christina and I and finds comfort in our arms. The doctors are monitoring Giovanni  vigilantly and are ready to take whatever measures they must to combat his symptoms. And as for the nursing and CNA staff at Childrens Hospital and the Specialized 6 West Transplant Unit the care is simply remarkable. We are now in day +11. 

 

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March 30, 2007

Saving Giovanni Day +9

 

Giovanni slept all night for dad. But he woke up crying. Rushing to his bedside I lifted him out of his crib and quickly sat down in the rocking chair to rock him only to feel  this familiar warm sensation on my hand when lifting him to see I was holding his spoiled bum. Damn, I said to myself, your crapping all over me this week but I still love ya. Reminds me of the construction business, which I'm no longer in--lost my business this week after five months of neglect but knew I would at some point when prioritizing Giovanni over business. No worries, I can always start another business but I can't get another Giovanni.

 

Giovanni's vitals are all good: no fever, blood pressure is great, labs are all clear, and he's lost less then a pound through this entire transplant process which is phenomenal. His weight is only down to 10.10 oz, from 11.6 when the process started. His bum is broken down badly from the mucositis, but we are keeping a close eye on it and being very generous with the Triple Paste--which is great. He also had a nice bath to soothe his butt.

 

Giovanni is still coughing up mucus, but overall the kid is doing great. He's sleeping a lot to deal with the pain but I'm seeing life through rose colored glasses and Giovanni parties to thank the thousands of people supporting him. He's the poster boy of this international movement to fill the International Registry with as many life-saving bone marrow donors as we can.  

  

March 29, 2007

Saving Giovanni Day +8

 

Last night was restless for Giovanni. He got up several times for Grandma to be changed and in need of further pain medication. At times not even holding him will give him the comfort he needs. Day +9 is approaching and we hope to move through this period as quickly as possible. His blood pressure is under control, no VOD sightings, and the mucocitis although present has yet to hit the severe stage. He is still doing remarkably well when compared to other children at the same stage.

 

We are happy or at least relieved that he is sleeping most of the time. Today, however, I held Giovanni and it was simply moving. Just holding him in my arms and feeling the warm glow traverse my body is intoxicating. As I sat holding him rocking in a chair I fell asleep. To hold and love your child is just so priceless, so, rewarding, so unexplainable in words. It frustrates me that my advanced higher education leaves me incapable of finding the necessary words to articulate how I feel for my child and how he's enriched my life more than any single experience I know. Maybe those feelings are love, that which in truely undefinable by words but recognized in emotion, feelings, in those physiological sensations that bathe ones body as they hold there own creation.

 

March 28, 2007

Saving Giovanni Day +7

 

Giovanni slept through the night, but his blood pressure is up, as well as his pain. He now has a morphine drip and no hair.  And at times not even mom can't console Giovanni. We were told Giovanni would suffer from day +7 through +14.  

 

Giovanni was awake and lucid for a while this morning, no smiles, but somewhat playful until the pain struck again and he was medicated. He later awoke pain free and enjoyed some afternoon physical therapy with Kristen.

 

As the afternoon pasted Giovanni's blood pressure continued to increase, as did his pain. He now has a medication patch to decrease his blood pressure and his pain medication is allowing Giovanni to sleep through much of his suffering.  Over the next 7 days we hope he sleeps as much as possible because there is no pain as great as that of watching your child suffer and standing there helpless and incapable of comforting him. 

 

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March 27, 2007

Saving Giovanni Day +6

 

Giovanni's pain is increasing and so is his pain medication allowing him to sleep in comfort. His liver enzymes were up today and his liver is swollen from all the chemo drugs his liver has detoxified and his blood vessels are dehydrated.

 

The doctors are concerned that Giovanni may be getting veno occlusive disease (VOD), of the liver, an uncommon complication following bone marrow transplantation thought to arise because of a nonspecific vasculitis arising in response to an inflammatory challenge, such as a BMT conditioning regimen. It presents with increasing weight gain, liver size, and elevation in total and direct bilirubin, as well as levels of alkaline phosphatase and gamma-glutamyltransferase (GGT).

The diagnostic finding on ultrasonography is reversal of flow in the portal and hepatic veins. Other findings on ultrasonography include ascites, decreased flow in the veins, and hepatomegaly. Ultrasonography is a powerful tool for confirming diagnosis, but classical findings are often late in the course or not always apparent; thus, it should not be relied upon to eliminate this diagnosis in the face of other evidence that would support it. A critical aspect of this disease is that, once it occurs, the chances for other systems to fail increase dramatically, and potentially fatal multiorgan system failure may occur. 

P
reliminary test show no signs. The doctors are being vigilent and engaging preventive medicine: Giovanni is getting platletts and blood to hydrate his blood vessels and push the toxins through his liver. It appears Giovanni may have overcome another difficulty, but further time will prove this belief.

 

He is becoming increasingly more uncomfortable, almost all of his hair is gone, yet he stills finds the strength to play a little with mom and dad. And while Aunt Rosie was reading him a book he slapped each page as she turned them. Day +7 is here and as predicted Giovanni is suffering further.

 

March 26, 2007

Saving Giovanni Day +5

 

First thing in the moring we called Aunt Rosie and she reported that Giovanni got up once during the night to be changed but was otherwise sleeping. She talked about how good Giovanni was for her all evening and in a shocking tone slowed stating he shot poop out of his bum all over me, the bed, and the floor. Christina and I laughed. He blessed you, I said. (I know that feeling)

 

Christina and I spent the afternoon with Giovanni and Aunt Rosie. He slept most of the time but when he woke he talked up a storm rolling around the crib and actually getting loud. He had a lot of strength. His smiles are still far and few between but the ones he gives are priceless.

 

Giovanni is starting to show the first sores of mucositis. There is a site in his mouth and his lips are turning white. More of his hair is falling out, and the doctors are planning to increase his pain medication. Over the next 10 days Giovanni will suffer the buring results of the chemo. We hate to see him suffer, he is sleeping for the most part, but the pain is more acceptable than the alternative. Giovanni has won another day...

 

As we sat down to eat I recieved a call from our Private Investigator Brian Blackden who informed me he had a tip on the thief who stole Giovanni's donations. He asked me if I wanted to take a ride to which I replied yes. I pushed myself from the table explaining to Christina I had to go whom objected not wanting me to get hurt but I need to defend my son's honor and for the good of society make this guy the social pariah he is.  Because he only committed a misdeameanor the police can do little to him.

 

Our first stop was the Lawrence PD so Brian could announce he was in the area looking for a wanted suspect. We then proceeded to the rooming house where the suspect supposedly lives and spoke to the management who said the picture looked like a guy in room one. We went up the stairs and I banged on the door. From behind the door we heard:

Who is it.

Baby Giovanni, I said

Who?

Baby Giovanni.

I'm sleeping.

Open the door, I yelled

 

When he opened the door I shoved Giovanni's picture in his face and said "you know this baby" to which he replied "no." I said "you steal his money," "No". I held the wanted poster in front of him saying "this is you, This is you," no he pleaded. The picture was a spitting image of this guy but he just didn't seem the type of person who would have the disposition. Such a person would have been more aggressive or even defesnive with me. He uncomfortably looked at the ground, not at me, and I said "I have a witness down stairs, will you meet the witness, get the witness." Yes, He said. Brian asked "can we take a picture of you." "Yes," he said.  We took the picture of him and left his room.  

 

Down stairs the management called the Lawrence police to see if they could make a report and while doing so the management faxed the poster to there other rooming house of the same name, Valley Lodge, that reported another person fit the picture and was a heroin addict. The police said they couldn't do anything and even if we had a NH warrant they could not arrest him nor would a court send him back to NH for a misdeameanor. It was true.

 

I was standing there with these police officers and they were sympathetic to baby Giovanni but there was nothing they could do. I immediately regressed to a mentality of days gone by and thought of exacting some street justice. No, I can't do that I answered myself. Yes, you can I retorted. No, no, can't do it. Yes, no. 

 

After talking we felt the guy didn't seem the type to pull off the scam so we went to the other rooming house. We met the management who said the guy was a friend of Freddy who was thrown out of the place. I asked if anyone else would know his name and they said a few other tenants might. The first guy said he didn't recognize the picture and the second wouldn't open his door. As we went down the halls a girl turned the hall and the manager called her. She was scared to talk--it was all over the neighborhood we were looking for this guy.

I can't tell you. No, I can't get involved he'll kill me. The polcie are after him for molesting a littel girl. He's a bad ass.

 

Come here, I'm not a cop. Tell me what you know.

 

No, no one can see me. If anyone sees me talking to you they'll call me a rat and kick my ass here. I wont be able to live here.

 

Come in here and talk to us the manager said.

 

I put a 50$ bill in her hand, the manager told her he would let her stay there another night. She told us the guy was a weight lifter, a bad ass, named Roberto Santos Jr, but the office records showed a photo ID of Jonnie S. Silvera. She knew where he lived but not the name of the streets and drew I map for us. I asked her if he was a junkie and a booster--a junkie who supports his habit by stealing--and she said "yes, he so smoothe he could talk a dog off a meat wagon." That's the guy I said to myself.

 

"Do you know where he is?" She began to cry stating he'll kill me, and I said no he'll never find out. I gave her another $20. "He's at the bar around the corner."

 

We left the rooming house and went to the bar. I took off my jacket, pumped, and walked into a neighborhood Spanish bar I had no business in like I owned it and every head turned. I walked the entire length of the bar looking at every person to see if he was there passing each table as the heads turned following me from one end back to the other. Brian and his partner stood by the door to watch my back, this was my beef, my son. Everyone looking I walked to the center of the bar holding up Giovanni's picture and the wanted poster. "Anyone in here know this guy, he stole from this baby. my baby. I'm no cop, I'm the baby's father, and I want this man. DO you know who he is. I have $4000 for anyone who brings me to him."

 

First the ladies came to me looking at the picture, then some men, fathers, and they all said no. Many of the people owned local businesses and asked for the poster to hang in there store. I thanked everyone, told them if they knew him or found out who he was to call America's Most Wanted tip line 1-800-CRIME-TV.

 

In the morning Brian will contact Sheriff DiPaloa who has jurisdiction in Massachusetts and give him the information we developed. The Sheriff and his men will find the guy soon. Watch.

 

Getting home at 12:30 I got on the computer and made my journal entries for Giovanni. It's now 2:38 am. I'm going to bed. In the morning I'll drive mom to the hospital and stay wth Giovanni for a while. Bring Aunt Rosie back to Concord, NH, and proceed to the bone marrow drive at Plymouth State University from 1 to 8. Then I'll return to Boston to see Baby Giovanni and tell him how many people he inspired to join the registry and hopefully save a kids life.

 

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March 25, 2007

Saving Giovanni: Day +4

 

Before I could settle in with Giovanni for the night I had to bring Mom and Grandma back to NH and then return to the hospital. As you all know it was snowing out--hard--and the ride was long and slow. When I finally got back to the hospital I walked in and upon seeing my sleeping baby boy Giovanni so peaceful I filled with pride and joy, as we all do when seeing our children. I slowly walked to his crib and lowered the rail so I could kiss Giovanni on his cheek and lay my head on his chest to fill myself with his love and reap his calming sensation. When I hug him and hold him close to me its just intoxicating. He fills me and I lay him back to rest. 

 

He slept well all night and I awoke to his groans of pain. I jumped from the bed and stepped to his side lowering the rail and scooping him up to my chest I soothed him. Restless I laid him down to check his diaper. It was wet so I went about changing him. The drugs he is on give him gas and diarrhea. As soon as I pulled down the diaper and folded it under him and began to clean him he quieted. Giovanni does not like a wet bum. Reaching over to get some Triple Paste--Giovanni's legs in the air--I returned as he pushed a stream of green crap all over my shirt and sweat pants. I don't know how the rest of you act when pooed upon but I smiled saying to Giovanni: "If anyone else did that to me I'd have to kick their ass, but I'm gonna give you a pass because I love ya."

 

After changing Giovanni and putting a new outfit on I laid him down and gave him his binky. He went back to sleep. He is sleeping a lot because the drugs and undoubtedly the trauma he's suffered durng the chemo process.

 

Grandma and mom arrived about 9:30am and I left for St. Athanasius Greek Church in Arlington for a Giovanni Bone Marrow drive where we put 122 new life saving bone marrow donors in the registry. Christina left threafter and proceeded back to New Hampshire to attend the St Anselm College Wiffle Ball Tounament and Bone Marrow Drive where they added 196-life-saving bone marrow donors to the registry.

 

After her drive Christina returned to the hospital with Aunt Rosie and I met her there. We all stayed with Giovanni for several hours holding him, talking to him, listening to him talk to us, and getting some smiles out of him. One more day of success.

 

 

March 24, 2007

Saving Giovanni: Day +3

 

Giovanni is eight-months-old today. He slept well all night for moma and upon waking immediately sought comfort in her the arms. He's a hug-a-holic and most assuredly deserves all such attention. Giovanni's pain was moderate today and he received several doses of morphine. He was animated and smiling, kicking his feet and cooing. The mucositis has yet to fully set in, but his mouth is starting to show signs of swelling and white discoloration. He's also gagging trying to push the itch and ulcers from his digestive and respiratory tracts. He needed oxygen several times today when he fell into deep states of sleep while sedated by morphine. 

 

He is, however, still handling things well. The nurses who take care of the transplant kids of 6 West are a wealth of knowledge and as attentive as a mother to child. We're told the mucositis will be at its worse between +7 to +14 days post transplant. Thus, Giovanni still has his fight with the mucositis stage as well as the cell grafting process. He's very calmed by the attention of me or Christina, especially her. When I comfort him he appears to look at me in aderation and draw strength from me when in reality he's my strength and fuels each step of my day. When looking at Christina his eyes and manner relax in a state of tranquility and he melts into her arms. 

 

For a child of eight months he has such personality. He conveys his disposition or condition with the look of an eye, a smile, a calming coo, the feel or slap of a hand, a stare or gleam of the eye, kicking his feet, the roll of his body or the throw of a shoulder. He's talking through body language. He knows pain and that his cry brings attention and comfort; joy in that his smile brings laughter and smiles in return.

 

A baby is a remarkable gift, which one cannot realize until that first minute when your child is passed into your arms and your body fills with a sensation that traverses your entire being in a warmth that bursts glowing smile on your face. Its the most powerful intoxicant one can feel--creating life. Indeed, the best gift I have or anyone will receive in life. 

 

We put 293-life-saving bone marrow donors in the registry today in Giovanni's name and know in time the work in his stead will  give the gift of life to many children who deserve life and the parents who deserve to bask in the glory of their child. Thank you everyone for poured into the bone marrow drives in hopes of saving a child: The most altruistic and noble thing one could possibly be honored to do in life.         

 

March 23, 2007

Saving Giovanni: Day +2

 

Giovanni actually rested well last night and woke up kicking and with a smile. It was wonderful to see. He's battling the side-effects of the chemo like a champ. His strength is simply remarkable. The mucositis has yet to fully impact, but were hoping that Giovanni will not get it severely. He's covered in rashes now, but the doctors feel its from medication and not the transplant. Rashes are the indicator of rejection or graft versus host disease. These are the terrors of the transplant process that you much face each day as the physiology of the body takes its natural course.

 

I can't express how honored I am to have Giovanni as my son. His strength is just phenomenal. This kid has lived in a hospital since November 7 enduring lumbar taps, hundrens of IV, blood draws, heal sticks, and the worse I witnessed was an arterial stick, which was a needle sunk into his wrist that intends to hit the pulse in your wrist. It's a blind stick. The doctor has to move the needle around to puncture the artery. I've watched Giovanni get an IV and not even cry, he's so assimilated to pain, but when I watched a needle sink over a half inch in his wrist and him scream in pain it killed me. But more amazingly, after the doctors sunk the needle and he screamed he then stopped as they were moving the needle around in his wrist feeling for the artery. It took three attempts before they were able to get the blood. It was the most painful thing I've witnessed him endure from a procedure, and only he can attest to the internal pains he's suffered.

 

Before the day ended, Giovanni had a bath. All this kid has been through and well sitting in the tub a big smile broke out across his face. With that note, I'll end the entry for day +2.

  

March 22, 2007

Saving Giovanni: Day + 1

 

Giovanni slept well for Grandma last night, but the moring is bringing difficulties. Mucositis is developing in Giovanni's mouth and airways thus reducing his air intake requiring as oxygen mask near his face. His pain level is also increasing as is the morphine he needs to remain comfortable. In the next few weeks Giovanni will struggle in his fight to graft and live. At the same time Christina and I feel like we are on that first hill of the roller coaster, the steepest one that instill the most terror and we can't get off.

 

We are, I guess, in an internal state of terror facing the unknown and waiting each minute, each hour, each day for good news while simultaneously conscious that any call, knock on the door, or even Giovanni's conidtion as we watch him could turn for the worse and even be fatal. It's a terrible feeling. I can't articulate it any better, just horrifying: the unknown.  

 

Today my son, our son, suffered. Nothing could consule him. I leaned over him and cupped his head in my arms, cradled him, layed my forhead against his forehhead, his cheeks, which would comfort him for a minute but end in his pain. I leaned over him looking, wondering why, just loving this little being, my orffsprint, beneath me suffering for no apparent reason. Why do I pity, why do I question, why should I seek consolance when my son--our son--lies suffering and I still persist on trying to reason why. Many people fall back to their faith believing God has a reason, why. What reason could any God have to allow a child to suffer for no reason of its own. The child not have lived--committed not sins, so why.  I cannot rationalize why.

 

March 21, 2007

Saving Giovanni: Day 10

The struggle for life begins

 

Giovanni slept well for Mom last night waking only once. This morning we're seeing the first signs of rashes breaking out around his body on his stomach, legs, and butt, and his lips are getting white from mucositis. Over the next two weeks Giovanni will worsen requiring morphine to dull his pain. He is currently being hydrated in preperation for the cord blood transfusion.   

  

The cord blood is a 5 out of 6 match and blood type O-, like Giovanni's. These are all good indicators. One advantage of cord blood over bone marrow is less graft versus host disease. On the other hand, there is no prebuild immune system with cord while there is with marrow.

 

After the transplant, Giovanni will face new life challenges: The most significant problem in the cord blood or stem cell transplantation is graft versus host disease (GVHD). It occurs because the donor's immune system (graft) identifies your cells or in the case Giovanni's (the host) as foreign or different and attacks them, causing skin rash, redness, gastrointestinal upset, and abnormal liver tests. These problems progress to blistering and loss of skin, liver failure, chronic diarrhea and gastrointestinal bleeding and may be fatal.

 

The acute form of GVHD may appear from one week to 3 months from transplant, and can progress into chronic GVHD characterized by skin, liver and intestinal problems as well as other debilitating complications. In the most extreme cases, they include skin tightening and contraction, liver failure, chronic diarrhea, breathing problems, poor bone marrow function and increased rates of infection. Chronic GVHD is most likely to arise after 3 months but during the first year after transplant. It can ocurr or worsen even later than 1 year.

 

Between 12:30pm and 2:30pm Giovanni received his cord blood transplant--a shot of life. It was both climactic and uneventful in that is was a simple blood drip. I'm conflicted over the whole process. On one hand it can save his life, on the other kill him. But without the cord or marrow he would most certainly die. I guess I feel...helpless. Filled with a sense of terror lasting six weeks as they draw blood each day looking for blood counts to register indicating graft or the replication of new cells. Three sucessful labs showing a 500 or better t-cell count is considered a success.

 

Giovanni looks drained. He's uncomfortable and under morphine. Grandma is with him right now. His smiles are now few and far between. His strength sapped from the course of drugs that ran through his tiny body over the last 10 days. I can remember as I held him he just melted in my arms--drawing comfort from me--and I just held him to my chest as closely as possible trying to hold him as tightly as possible without hurting him so he could feel my love, strength and hope for him. This is just horrific--and I feel selfish for its my son whom is suffering and struggling for life and I seek comfort, or is it hope, as answers to the unknown that faces us, him. I can't but feel my son is paying for the sins of the father, me, why my son. Why anyone's?

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March 20, 2007

Saving Giovanni: Day Nine

 Last Day of Chemo/medication

 

Giovanni experienced more vomiting during the night, but still not severe. Mucocitis is coming, his tongue is showing signs and his discomfort level is increasing--we dreg his pain. I wish I could subsum his pain, his sickness, lay in his stead but as parents we don't have that option and must instead suffer with our children. We're thankful, however, for our family, friends, and the thoudsands of people all over the country and world helping us, giving us strength, and praying for Giovanni. If it wasn't for everyone helping we could not be by Giovanni's side during all of this, and for the next few months, and we are forever grateful.

 

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Giovanni, as you can see is losing more of his hair, and I will shave mine in solidarity with my son--as have many other fathers for their children. The cord blood transplant is tomorrow--a life or death infusion. But absent this action Giovanni would eventually die of infection. Because we cannot find a bone marrow match in the most powerful country in the world our child unnecessarily lanquished in the hospital when he insteady should be recovering. Our system is broken. Indeed,  its unconscionable that 35% of the children waiting for a bone marrow match die asking their father or mother "did they find a match for me today...." Thus, unable to find a bone marrow transplant to date we can wait no longer for fear that Giovanni's condition will further deteriorate and kill him.  

 

Over the next six weeks Giovanni faces the challenge of his life, one he has the strength to win. After the last nine days of chemo and medication called the "conditioning" phase, and the infusion of the cord blood there are many risks that can occur. There is a high risk of bleeding and or infection because of the low blood counts. Giovanni will remain in the protected enviroment of the transplant room and will be treated with oral and intravenous antibiotics and transfusions to protect from infection or bleeding.

 

Despite the fact that all of the transfused blood products are specially screened, there is a small risk of acquiring a blood borne infection such as hepatitis or HIV. If the donated cells do not grow, Giovanni will most likely die from infection or bleeding. Event if the new stem cells grow, death from bleeding or an infection is a possibility.

 

In the morning,  it shall be life for Giovanni because after all he's suffered and survied these last seven months he deserves to live.

 

March 19

Saving Giovanni: Day Eight

 

Giovanni slept well through the night for Aunt Rosie, but he did vomit a few times. There are no signs of the below listed side effects with the exception of high blood pressure. Giovanni's blood pressure is running a little high, but no alarms. He's handling the chemo remarkably well and we hope things continue to go this way. 

 

Giovanni was giving away kisses all day, but when I got there he was all out. He did let me hold him and rock him to sleep. He's doing a lot of sleeping. The first stages of mucocitis are beginning to appear and there is no mercy with that side effect. It will be painful for at least two weeks and he will suffer although morphine will help. He's wants to be held most of the time. Once you rock him to sleep if you lay him back in the crib he wakes up crying and wants to be held. He deserves it so that's what we will do. His hair is getting thinner. I'm sharpening my razor. One more day to go to finish chemo.

 

Aunt Rosie and Giovanni

 

 

March 18

Saving Giovanni: Day Seven

 

At 3:30pm Giovanni started his first dose of antithymocyte globulin (ATG) to run over a six hour period three times a day for the next three days. In addition, he begins methylprednisolone three times a day for the next three days. The potential sides effects of each are as follows:

 

Antithymocyte globulin (ATG)

 

Associated with fever, feeeling weak, joint pains, rash, low blood counts, hemolysis, which is a breakdown of red cells in the blood. More severe toxiicities include hives, difficulty breathing, and low blood pressure (hypotension).

 

Methylprednisolone 

 

The side effects if this drug, which is a steroid hormone that can suppress the immune system, include increased risk of infection, cataracts, high blood pressure, high blood sugar, hig blood fats, stomach upset including ulcers, and bone damage including osteoporosis (weak bones) and aseptic necrosis (bones with poor blood supply). SOme patients will have mood swings while on steroid treatment.  

 

Giovanni has been monitored for the rash with respect to the ATG side effect and is clear so far. He still remains comfortable, slept through the night, and is still in good spirits giving lots of smiles when he's not sleeping. He is having a lot of drugs pumped through him as well as morphine to reduce his pain. 

 

There are no signs of mucocitis yet. Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract. It can occur anywhere from the mouth to the anus. In the oral cavity and esophagus, mucositis is characterized by painful ulceration. Further down the digestive tract, mucositis causes diarrhea, often severe and debilitating. Mucositis is a common side effect of chemotherapy and of radiotherapy, occurring to some degree in approximately 40% of patients who receive cancer chemotherapy. The oral cavity or mouth is the common site for mucositis.

 

We are watching Giovanni's mouth closely and he's still sucking away on his binky, so all is well for now. Aunto Rosie is here and she will be taking over for the night.

 

 

March 17, 2007

Saving Giovanni: Day Six

 

Giovanni sails through day six with no visable side effects. He was smiling, talking, kicking his legs and sleeping comfortably. He even had two bottles of 10cc each without throwing up, but he's losing his hair from the chemo. I may have to shave my head to be like my baby boy. The cyclophosphamide ends tonight.

 

Gift t-shirt from Teamsters President Sean O'Brien to Giovanni


 

March 16, 2007

Saving Giovanni: Day Five

 

Giovanni had mom up all night. He was very upset and obviously suffering from the new drug. There was no comforting him and the only option was morphine. He rested for the remainder of the night and was sedated for most of the morning. I arrived in Boston by 9am with grandma to watch Giovanni in the evening so Christina and I could later attend the Giovanni Comedy Night and Benefit Dinner, which is a story in itself or should I say sad joke.

 

When I entered Giovanni's room I walked to his side and laid my cheek against his as he soundly slept softly breathing. As my cheek lay against  his puffy cherib cheeks feeling his warmth I selfishly fed myself comfort from this touch me a mere weak mortal to his constant strength. My skin against his I just laid there as I completely surrendered my love for my child and allowed my body to bathe in it like a powerful drug filling me with peace and completeness. I love my child so much I can't find adequate words to express it.

 

Giovanni then awoke looking up at me and grandma and as I registered in him mind a beautiful smile broke across his face and I closed my eyes capturing it in my mind and imprinting it for eternity. His smile bliss, like no drug or happiness I've ever felt--that is parenthood.

 

Touching my face and sharing each other's comfort he fell off to sleep again. Stepping back from his crib I again discerned he had conqoured another day. A survivor, indeed, that is he.

 

A doctor came in late moring and told me they identified Giovanni's infection: Citrobacter (Sit-row-back-tur)– Genus belonging to the family Enterobacteriaceae. It is found in the feces of humans and animals and can be an opportunistic pathogen. Giovanni, as he did in other hospitals before Childrens poisoned himself via his intestines for lack of an immune system. 

 

We were also told this bateria has the potential to create seizures or abceses in the brain, which could require brain surgery worse case scenario to remove such growths. I asked about signs and symptoms and the doctor said unconsolable. He was that way last night, I said. No, completely unconsolable she stated. I asked whether she thought his brain was infected and she said he didn't show any signs and the antibiotics began many days ago most likely killig the infection but an MRI was needed to be sure. We were told it would be perfomed as soon as the machine was available.

 

Kissing Giovanni I left to assist in the organization of the Irish American Association bone marrow drive on March 12, in Malden. While out Christina headed back to NH but first to Haverhill to pick up Alex and Adrian from there father's home so they could attend Giovanni's Benefit Comedy Diner. Snow storm in full throttle it took Christina four hours to get home after which she headed to Concord for the diner. I left Boston at 3pm and arrived in Concord at 7:30 pm. Due to weather conditions, only the most tenacious Giovanni supporters--with four wheel drive vehicles--could make the diner. No word from gramdma on the MRI.  

 

At 12:30 the MRI came back negative. Giovanni comes through again. Throughout the night he woke up crying, irritated uncomfprtable, but grandma was able to comfort him and rock him back to sleep. Day six begins.  

 

 Giovanni listenting to some music while getting his blood pressure done

 

March 15, 2007

Saving Giovanni: Day Four

 

Giovanni awoke about 8am with two wonderful nurses showering him with attention. He has been resting comfortably all morning and even played with me some, which means I get a few well delivered slaps in the face with some petting. Yes, he likes to pet me too and I'm happy to be his dog. He was kicking his legs and throwing his hands around and I sit here in absolute awe that my beautiful little Giovanni baby struggling for life with poison coursing through his body to save his life has once again bounced back after throwing us in a state of complete fright. I was so scared Wednesday morning when Christina called me at home I actually lost control for a minute and  had to regain control of myself.

 

Mommy arrived at 12:30 and Giovanni snapped his head around as soon as he heard the door open knowing who was coming through the door. I left the hospital and proceeded to the JFK Library with Mark Lanoue where as an invited guest I spoke before the Massachusetts AFL-CIO COPE Political Education Roundtable. Giovanni will soon appear on the AFL-CIO website, and this Giovanni's site will soon display the many unions logos that suport the goal of Save Giovanni to fill the registry with bone marrow donors to save the lives of the many children who will die without a marrow match.

 

When I returned this afternoon with a surprise meal for mom from the North Ends Cantina Italiana Giovanni was comfortably laying on the bed his arms and legs stretched out as mom carfully washed him while he sucked away on his binky like that little baby on that Simpson's cartoon.

 

It's now 6:30pm and I'm headed back to NH for some sleep,  and to upload the daily pictures of Giovanni. Mom will keep me posted as to Giovanni's condition. He has two final doses of busulfan, day four will end, and the second chemo drug will begin.

 

At 2:30 am the first state of chemo ended and the second drug, cyclophosphamide, began. The risks of this drug are described as follows: "...will cause temporary hair loss and stomach and intestinal upset, and may cuse temporary salt and fluid imbalance (water retention)...bladder irritation leading to burning on urination and bloody urine ... rarely leads to permanent damage. You will recieve large amounts of IV fluids for several days to limit bladder irritation. The drug also has been know to cause fatal heart failure in rare instances. Rarely, cyclophosphamide can cause liver and lung irritation. There may also be the possibility of permanent sterility and other unexpected long-term side effects."

 

Giovanni after surgery  

 

March 14, 2007

Saving Giovanni: Day Three

 

This morning we were very worried about Giovanni and his declining condition. He's now stable but no longer conscious or playful like yesterday. He's slept most of the day, his body exhausted. His vitals have stabilized, but his oxygen levels are erratic. Each time it drops to 90 he get oxygen from a mask in his crib. Giovanni is waiting for a surgical room to open so that his central line can be removed. A temporary line will be placed in his neck until the the three antibiotics kill his infection. We will keep everyone informed of Giovanni's condition as the day proceeds.

 

This morning we were very worried about Giovanni and his declining condition. He's now stable but no longer conscious or playful like yesterday. He's slept most of the day, his body exhausted. His vitals have stabilized, but his oxygen levels are erratic. Each time it drops to 90 he get oxygen from a mask in his crib. Giovanni is waiting for a surgical room to open so that his central line can be removed. A temporary line will be placed in his neck until the the three antibiotics kill his infection. We will keep everyone informed of Giovanni's condition as the day proceeds.

 

Giovanni's vitals are stable. He is still resting. We stepped out for a few minutes to see the donated Clear Channel billboard unvailed, took some pictures, did a few interviews and quickly returned to the Hospital to be with Giovanni. He later broke his central line, but only one port which will allow the chemo to proceed. Once you start the chemo you can't stop.

 

Giovanni awoke for a little while around 9:30 pm and as soon as he saw me and mom began to smile. It just goes right through you but it was so reassuring. He's bouncing back again.

 

Giovanni played with mom and a few toys, I put my face down near him letting him touch my face as he likes and after touching me for a while to feel my presence he slapped me a few times. He then fell back off to sleep. Day three of the busulfan is almost over. His vitals are stable, and all I can say is Giovanni is the strongest man I've ever known. That which does not kill you only makes you stronger.

 

Mom was up with Giovanni all night as his slid near the crashing point and left at 10:45 to go back to NH and sleep. Giovanni has yet to be called for surgery. I'm told he should go down by 2am. I will keep you all posted as the night proceeds. 

 

5:44am Giovanni is out of surgery and back in his room. While sitting with him in recovery he awoke and began to cry. Opening his eyes he saw me at his side and as I grabed him and held him in my arms covered with a hot blanket from a nurse he calmed. I then placed him back in the bed covered with the blanket and sitting at the side of the bed he just tilted his head towards me and starred. I just sat looking at him and felt a sence of warmth engulf me--it was pride--as I sat looking at my baby emerge from another surgical procedure only seven-months-old I was proud of him, his strength, his inherent determination to live. 

 

I called mom to let her know her baby was well and she asked me to kiss him for her. She then told me to get some sleep--I've been awake for over 22 hours--and at 1:30pm I'll appear before the AFL-CIO Political Educational Roundtable seeking the support of the unions to help Giovanni  fill the bone marrow registry with the people of Masschusetts to save the lives of the many children who may die without a bone marrow match. Day four of chemo begins....

  Giovanni before surgery

 

 

March 13, 2007

Saving Giovanni: Day Two

 

Giovanni began his second day of chemo and experienced his first side-effects: diarrhea, he vomitted, he developed one fever, which broke and then got a second fever in the evening. The doctors began the antibiotics. Aunt Rose said she cried last night as she held sleeping Giovanni in her lap and he slightly opened his eyes looking up at her as if saying "I hope they aren't going to pump too much more of this stuff into me."  

 

Giovanni slept off and on all day comfortably for the most part and he gave lot of smiles ro Aunt Rose, the nurses and most of all mom. Each time she walked away from his crip for a minute he twisted his head trying to follow her anywhere she went starred until she returned and he once again fell off to sleep with her leaning over him on his crib or holding him. Tomorrow is day three of busulfan, one more day to go, and  when four days of cyclophosphamide begin.

 

Although Giovanni had few side effects I could still saw fear in Christina's eyes like a dear in the dark starring into your headlights on a dark road. The fear is like your standing on the edge of a clift in absolute fear of falling and the panic of falling never abates, it just keeps going all day long until your stomach aches and knots up. Giovanni's face always in front of your looking at you even when your eyes are closed and you're just helpless. Helplessness just eating at you as you try to accept the fact that you can't do anything to change the natural course of action that his body will follow. All you can do is hope nature is merciful.

 

Giovanni's condition worsened overnight. His heart rate peaked at 251, his blood pressure increased requiring medication than dropped too low requiring further medication. His oxygen levels dropped to the point that oxygen was provided, and as the night went on Giovanni became increasigly uncomfortable at which point Christina requested morphine for Giovanni. An x-ray was done to check his lungs that was negative. Labs were drawn and we were just infomed that gram negative baxteria is growing in Giovanni requiring the removal of his central line. He will go in for surgery today, his chemo will continue, and if his blood pressure continues to increase or decrease Giovanni will be moved to ICU. 

 

Mom and Giovanni second day of chemotherapy

 

Aunt Rose hugging Giovanni before leaving

 

March 12, 2007

 Saving Giovanni: Day One

 

The first thing I saw this morning when I awoke a 4am was a bottle of scotch on my dresser and thought I should take a slug from it to dull my senses as Christina and I began our 100 mile journey to the side of Giovanni for the first day of the rest of his life. As we begin the chemo treatment I will chronicle every step for the book I write, Saving Giovanni, so other parents will have an idea of the transplant process and how to hold bone marrow drives to save their child. It will be a guide so to speak through hell to eventual bliss in the survival of one's child one can only hope or pray.

 

Giovanni began his first two hour chemotherapy treatment of busulfan at 6am to be followed by three others every six hours for four days. According to the consent form: Busulfan frequently causes vomiting on the days it is being administered. Anti-nausea medication will be given to minimize or prevent vomiting. Temporary diarrhea can occur 1-2 weeks after administration of Busulfan. Other temporary side effects are hair loss (frequently) and increased color of skin (hyperpigmentation), which occurs occasionally. Rarely, convultions (seizures) may occur on the days that busulfan is being administered. Medication will be given to prevent or minimize risk. Some patients may develop abnormal function of the liver or lungs, which may be mild, moderate, or potentially fatal if severe. When given with other chemotherapy drugs, busulfan frequently causes problems with fertility.

 

When we walked in Giovanni's room he was looking up at us with helpless eyes and then smiled at us just breaking my heart knowing poision would soon course through his body either killing him, making him steril, or saving him. Aunt Rosie was asleep on the bed.

 

Mom went to Giovanni's side and began hugging him telling him she loved him while softly sobbing, and he looked over her shoulder at me almost knowing we were helpless to help him. When mom got up I layed my head on his chest holding his hands wishing I could absorb his sickness and lay in his place. Letting Giovanni's hands go he began cooing and feeling my face. The touch of his soft tiny hands paddling across my face and forehead was completly euphoric yet a sense of helplessness and multitude of other emotions consumed me in the most horrific and devastating numbing I've ever experienced.

 

Shaking myself from my selfish pity in the face of Giovanni not even conscious of his ensuing life or death trial I kissed him on both cheeks while leaning over his crib watching him in complete awe and honor to have him as my son as he fell off to sleep. I have never loved something so much in my life, I just want him to live.

 

Before the fist day ended, Giovanni had seven blood draws to test the levels of Busulfan in his blood and how his body was metabolizing the drug. He later recieved a transfusion to replace the blood he lost from testing.  

First day of chemotherapy

 

Mom sleeping on the wall exhausted after first chemo treatment

 

 

March 8, 2007

 

Giovanni has hit his all time weight 10.67, as well as his next life and death struggle. On Sunday Giovanni will be moved to the transplant floor in Children's Hospital and begin chemo